1) Several institutions have reported long term outcomes of patients with T1-2N0 SCC of the glottis treated with definitive radiotherapy.
Prepostions of and with.
With: use : 1) accopanying 2) by means of
Our institution has reported…
I would have written…Many institutions have reported long term outcomes of pts with T1 SCC of glottis treated by definitive raduiotherapy. I mgiht have doen mistake with use of ‘with’ or ‘by’.
Little more than that several would be enormous…
2) The five-year local control (LC) rates have ranged from 82-94% for T1a, 80-93% for T1b, 62-94% for T2a, and 23-73% for T2b. We report our first 20 year institutional outcome, and identify patient, tumor, and treatment related factors associated with inferior outcomes.
Prepsent perfect to simple present.
3)Patients were excluded if they previously had major surgery of the neck or the glottis, had a synchronous primary, or had received chemotherapy.
Subordiante clause begin with “if”.
If as conditional subordinate conjunction.
Position of adverb “previously”.
Exclusion criteria: 1) If pt had any major surgery in past
2) if patients is with other primary condition
3) If patient had received crt in past.
For example, if ca larynx patients was with HIV, was he excluded from the study???
4) Minor surgery (stripping for squamous cell carcinoma in-situ (SCIS) or minor cordotomy) was allowed.
The bracket content I would say is adjective.Simple past.
5)The AJCC 6th edition was used to stage all patients, but with further sub-classification of T2 patients.
In other words..
The AJCC 6th edition was used to stage all patients; however, T2 patients were further classified.
Despite use of the AJCC 6th editioin in staging patients, T2 patients were further classfied.
use of article “the”
The APHA new edition, The New England Jounral of Medicine , The AJMA 6th eiditon.
Preposition “with” ..by means of . Prepostion “of”
Use of passive voice in first main clause.
6) Patients were staged as follows: T1 included tumor confined to a single vocal cord (T1a) or both vocal cords (T1b) with normal vocal cord mobility; T2 included tumor with supra- or subglottic extension and further subdivided into T2a (without) or T2b (with) impaired vocal cord mobility.(Khan, Koyfman et al. 2012)
How were patients staged? Patients were staged in accordance with the AJCC 6th edition guidelines.
Khan, M. K., et al. (2012). “Definitive radiotherapy for early (T1-T2) Glottic Squamous cell carcinoma: a 20 year Cleveland clinic experience.” Radiat Oncol 7: 193.
PURPOSE: To report our 20 yr experience of definitive radiotherapy for early glottic squamous cell carcinoma (SCC). METHODS AND MATERIALS: Radiation records of 141 patients were retrospectively evaluated for patient, tumor, and treatment characteristics. Cox proportional hazard models were used to perform univariate (UVA) and multivariate analyses (MVA). Cause specific survival (CSS) and overall survival (OS) were plotted using cumulative incidence and Kaplan-Meir curves, respectively. RESULTS: Of the 91% patients that presented with impaired voice, 73% noted significant improvement. Chronic laryngeal edema and dysphagia were noted in 18% and 7%, respectively. The five year LC was 94% (T1a), 83% (T1b), 87% (T2a), 65% (T2b); the ten year LC was 89% (T1a), 83% (T1b), 87% (T2a), and 53% (T2b). The cumulative incidence of death due to larynx cancer at 10 yrs was 5.5%, respectively. On MVA, T-stage, heavy alcohol consumption during treatment, and used of weighted fields were predictive for poor outcome (p < 0.05). The five year CSS and OS was 95.9% and 76.8%, respectively. CONCLUSIONS: Definitive radiotherapy provides excellent LC and CSS for early glottis carcinoma, with excellent voice preservation and minimal long term toxicity. Alternative management strategies should be pursued for T2b glottis carcinomas.